MBS 430 - Systems Immunology

5 CR

This course is an introduction to molecular immunology. Topics include an overview of the immune system, antibody and T-cell receptor structure and function, genes of the immunoglobulin family, cells and molecules that mediate the immune response, and medical applications of modern immunology.

Prerequisite(s): MBS 340 and CHEM 406 with a C+ or higher for Molecular Biosciences BAS students, MBS 340 and CHEM 406 with a C or better for non-matriculated MBS students, or permission of program chair.

Course Outcomes

Identify the components of the immune system.
Illustrate in detail the structures of antibodies and T-cell receptors and the interaction between antigens and antibodies.
Examine the role of major histocompatibility complex (MHC) molecules in immune responses.
Explain T and B-cell activation by antigens and the generation of antibody and T-cell receptor diversity.
Classify cell types, molecules and pathways by their innate and antibody-mediated effector functions.
Explain the molecular and cellular interactions in inflammation.
Discuss the innate and adaptive defense mechanisms against different microbes.
Discuss the role of the immune response in health and disease.
Examine current immunotherapeutic approaches.

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