MBS 350 - Bioinformatics

5 CR

Topics include protein and DNA sequence alignments, evolutionary analysis and phylogenetic trees, obtaining protein secondary structure from sequence, and analysis of gene expression including clustering methods.

Prerequisite(s): MBS 340 or equivalent, with a C or higher.

Course Outcomes
At the end of this course students will be able to: • Access sequence data on appropriate databases for DNA, RNA and proteins. • Explain and perform pairwise and multiple alignment methods. • Understand and use BLAST (Basic Local Alignment Search Tool) proficiently, together with some more advanced related programs. • Apply different computational strategies used to predict the 3D structure of new proteins. • Explain the experimental techniques used in expressional and functional proteomics and the role of bioinformatics in analyzing the data. • Perform motif and domain searches in protein databases. • Explain microarray technology and microarray data analysis.

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