MBS 430 - Systems Immunology

5 CR

This course is an introduction to molecular immunology. Topics include an overview of the immune system, antibody and T-cell receptor structure and function, genes of the immunoglobulin family, cells and molecules that mediate the immune response, and medical applications of modern immunology.

Prerequisite(s): MBS 340 and CHEM 406 and with a C or higher.

Course Outcomes
At the end of this course students will be able to: • Identify the components of the immune system. • Illustrate in detail the structures of antibodies and T-cell receptors and the interaction between antigens and antibodies. • Examine the role of major histocompatibility complex (MHC) molecules in immune responses. • Explain T and B-cell activation by antigens and the generation of antibody and T-cell receptor diversity. • Classify cell types, molecules and pathways by their innate and antibody-mediated effector functions. • Explain the molecular and cellular interactions in inflammation. • Discuss the innate and adaptive defense mechanisms against different microbes. • Discuss the role of the immune response in health and disease. • Examine current immunotherapeutic approaches.

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